Hi Fiona

Methotrexate builds up in the system slowly and for the first couple of months is likely to have little effect. Consequently your joints continue to suffer. Usually by 13 weeks or so you should be feeling some benefit but it can take as much as 5 months if you are only on a low dose. The dosage is sometimes increased quite slowly to help avoid side effects.

Hope you feel some benefit soon,

Lyn x

Hi Fiona,

I've been taking MTX for 4 years now, around the 12 week marker I found the difference in my joints. I started on a very low dose and built up slowly week by week until I reached 15mg. Try taking it at night before you go to sleep, you then sleep through the side affects. I used to find I felt sick the day I took it. It could last for hours and the sun bothered me too. A high sun factor is important. I can feel a bit tired the following day I take it, but I do not really have any problems now...... Other than the fact I hate taking it, but I know I would be in a sorry state without it, so needs must.

Hope you settle down soon.

Take care Lorna x